Microenvironmental GABA Signaling Regulates Melanomagenesis through Reciprocal Melanoma–Keratinocyte Communication

Summary: GABA signaling by melanoma cells was found by Tagore and colleagues to trigger keratinocyte-driven growth of melanomas. This study reveals new roles for nonneuronal signaling by a neurotransmitter in regulating tumor initiation and outgrowth. See related article by Tagore et al., p. 2270 (4).