A vinyl-decorated covalent organic framework for ferroptotic cancer therapy via visible-light-triggered cysteine depletion

lipid raft- and caveolin-related endocytosis and induces lipid peroxidation and ferroptosis by consuming cysteine, exhibiting powerful therapeutic activity against colon cancer. We believe that this study both enriches the ambient synthesis of nanoscale COFs and highlights the feasibility of intracellular photochemical reactions for tumor therapy.