SIRT1 Stabilizes β-TrCP1 to Inhibit Snail1 Expression in Maintaining Intestinal Epithelial Integrity to Alleviate Colitis

DSS-induced mouse colitis is caused by the inhibition of the SIRT1, leading to β-TrCP1 degradation and Snail1 stabilization, resulting in disruption of cell adhesion and tight junction, accompanied by the integrity loss of the epithelial barrier and increased inflammation, which can be alleviated by NMN.