对映选择合成
螺旋烯
手性(物理)
立体中心
有机催化
催化作用
组合化学
环加成
化学
立体化学
分子
纳米技术
材料科学
有机化学
物理
对称性破坏
量子力学
手征对称破缺
Nambu–Jona Lasinio模型
作者
Wei Liu,Tianren Qin,Wansen Xie,Xiaoyu Yang
标识
DOI:10.1002/chem.202202369
摘要
Helicenes and helicene-like molecules, usually containing multiple ortho-fused aromatic rings, possess unique helical chirality. These compounds have found a wide range of important applications in many research fields, such as asymmetric catalysis, molecular recognition, sensors and responsive switches, circularly polarized luminescence materials and others. However, the catalytic enantioselective synthesis of helicenes was largely underexplored, when compared with the enantioselective synthesis of molecules bearing other stereogenic elements (e.g. central chirality and axial chirality). Since the pioneer work of asymmetric synthesis of helicenes via enantioselective [2+2+2] cycloaddition of triynes by Stará and Starý, last two decades have witnessed the tremendous development in the catalytic enantioselective synthesis of helicenes. In this review, we comprehensively summarized the advances in this field, which include methods enabled by both transition metal catalysis and organocatalysis, and provide our perspective on its future development.
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