Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Prepared by Coprecipitations Method for Hyperthermia Therapy

Magnetic nanoparticles (Fe 3 O 4 ) have considerable attention in various biomedical applications such as biosensors, drug delivery systems in the body, magnetic resonance imaging (MRI), and hyperthermia therapy. Hyperthermia therapy uses heat controlled by applied AC (Alternating Current) magnetic to kill cancer cells. This research aims to determine the effect of changes in temperature caused by the AC magnetic field on the varied magnetic nanoparticle solution. The Synthesize of Fe 3 O 4 used the coprecipitation method to produce Fe 3 O 4 nanoparticles. Mass of Fe 3 O 4 nanoparticles varied of 95 mg and 125 mg. Nanoparticles physical properties were characterized using X-ray diffraction (XRD), Scanning Electron Microscope (SEM), and vibrating sample magnetometer (VSM). XRD profiles indicated that magnetic (Fe 3 O 4 ) nanoparticles were successfully synthesized with a crystal size of 7.76 nm. SEM characterization of Fe 3 O 4 nanoparticles was carried out at a magnification of 150.000 times and the average diameter of Fe 3 O 4 powder nanoparticles was 20 nm. The temperature change measurement was performed using an AC magnetic field of 2.8 mT and frequency of 343 Hz, and time recorded changes temperature in 660 seconds. The temperature changes for solution concentrations of 95 mg and 125 mg were 7.7°C and 9.8°C, respectively. the concentration of solutions affects the value of the Specific Absorption Rate (SAR). The SAR values of each concentration of Fe 3 O 4 solution were 0,0069 W/g and 0.0096 W/g. It proves that Fe 3 O 3 prepared by coprecipitation method has potential for hyperthermia therapy application.