微生物群
精神分裂症(面向对象编程)
海马结构
医学
普雷沃菌属
精神科
失调
阳性与阴性症状量表
临床心理学
精神病
心理学
生物信息学
内科学
生物
遗传学
细菌
作者
Jakleen Lee,Enrica Piras,Sabrina Tamburini,Kevin Bu,David S. Wallach,Brooke Remsen,Adam Cantor,Jennifer Y. Kong,Deborah Goetz,Kevin W. Hoffman,Mharisi Bonner,Peter Joe,Bridget R. Mueller,Jessica Robinson‐Papp,Eyal Lotan,Oded Gonen,Dolores Malaspina,José C. Clemente
标识
DOI:10.1016/j.psychres.2023.115279
摘要
Although increasing evidence links microbial dysbiosis with the risk for psychiatric symptoms through the microbiome-gut-brain axis (MGBA), the specific mechanisms remain poorly characterized. In a diagnostically heterogeneous group of treated psychiatric cases and nonpsychiatric controls, we characterized the gut and oral microbiome, plasma cytokines, and hippocampal inflammatory processes via proton magnetic resonance spectroscopic imaging (1H-MRSI). Using a transdiagnostic approach, these data were examined in association with schizophrenia-related symptoms measured by the Positive and Negative Syndrome Scale (PANSS). Psychiatric cases had significantly greater heterogeneity of gut alpha diversity and an enrichment of pathogenic taxa, like Veillonella and Prevotella, in the oral microbiome, which was an accurate classifier of phenotype. Cases exhibited significantly greater positive, negative, and general PANSS scores that uniquely correlated with bacterial taxa. Strong, positive correlations of bacterial taxa were also found with cytokines and hippocampal gliosis, dysmyelination, and excitatory neurotransmission. This pilot study supports the hypothesis that the MGBA influences psychiatric symptomatology in a transdiagnostic manner. The relative importance of the oral microbiome in peripheral and hippocampal inflammatory pathways was highlighted, suggesting opportunities for probiotics and oral health to diagnose and treat psychiatric conditions.
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