组织工程
静水压力
干细胞
生物医学工程
材料科学
脂肪组织
极限抗拉强度
机械负荷
间质细胞
拉伤
间充质干细胞
刺激
化学
工程类
解剖
复合材料
细胞生物学
医学
神经科学
生物
机械
病理
物理
生物化学
作者
Rachel C. Nordberg,Josie C. Bodle,Elizabeth G. Loboa
出处
期刊:Methods in molecular biology
日期:2024-01-01
卷期号:: 349-365
标识
DOI:10.1007/978-1-0716-3762-3_25
摘要
It is critical that human adipose-derived stromal/stem cell (hASC) tissue engineering therapies possess appropriate mechanical properties in order to restore the function of the load-bearing tissues of the musculoskeletal system. In an effort to elucidate hASC response to mechanical stimulation and develop mechanically robust tissue-engineered constructs, recent research has utilized a variety of mechanical loading paradigms, including cyclic tensile strain, cyclic hydrostatic pressure, and mechanical unloading in simulated microgravity. This chapter will describe the methods for applying these mechanical stimuli to hASC to direct differentiation for functional tissue engineering of the musculoskeletal system.
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