2型糖尿病
糖尿病前期
磁共振弥散成像
医学
2型糖尿病
血管周围间隙
糖尿病
扩散
张量(固有定义)
物理
磁共振成像
病理
内分泌学
数学
放射科
纯数学
热力学
作者
Rukeye Tuerxun,Koji Kamagata,Yuya Saito,Christina Andica,Kaito Takabayashi,Wataru Uchida,Seina Yoshida,Jun Kikuta,Hiroki Tabata,Hitoshi Naito,Yuki Someya,Hideyoshi Kaga,Mari Miyata,Toshiaki Akashi,Akihiko Wada,Toshiaki Taoka,Shinji Naganawa,Daisuke Sugimoto,Hirotaka Watada,Ryuzo Kawamori,Shigeki Aoki
标识
DOI:10.3389/fnagi.2024.1362457
摘要
Background and purpose Glymphatic system in type 2 diabetes mellitus (T2DM) but not in the prodrome, prediabetes (Pre-DM) was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS). Association between glymphatic system and insulin resistance of prominent characteristic in T2DM and Pre-DM between is yet elucidated. Therefore, this study delves into the interstitial fluid dynamics using the DTI-ALPS in both Pre-DM and T2DM and association with insulin resistance. Materials and methods In our cross-sectional study, we assessed 70 elderly individuals from the Bunkyo Health Study, which included 22 with Pre-DM, 18 with T2DM, and 33 healthy controls with normal glucose metabolism (NGM). We utilized the general linear model (GLM) to evaluate the ALPS index based on DTI-ALPS across these groups, considering variables like sex, age, intracranial volume, years of education, anamnesis of hypertension and hyperlipidemia, and the total Fazekas scale. Furthermore, we have explored the relationship between the ALPS index and insulin resistance, as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) using GLM and the same set of covariates. Results In the T2DM group, the ALPS index demonstrated a reduction compared with the NGM group [family-wise error (FWE)-corrected p < 0.001; Cohen's d = −1.32]. Similarly, the Pre-DM group had a lower ALPS index than the NGM group (FWE-corrected p < 0.001; Cohen's d = −1.04). However, there was no significant disparity between the T2DM and Pre-DM groups (FWE-corrected p = 1.00; Cohen's d = −0.63). A negative correlation was observed between the ALPS index and HOMA-IR in the combined T2DM and Pre-DM groups (partial correlation coefficient r = −0.35, p < 0.005). Conclusion The ALPS index significantly decreased in both the pre-DM and T2DM groups and showed a correlated with insulin resistance. This indicated that changes in interstitial fluid dynamics are associated with insulin resistance.
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