噪音(视频)
生物系统
单元格大小
指数增长
计算机科学
统计物理学
物理
生物
量子力学
人工智能
细胞生物学
图像(数学)
作者
Motasem ElGamel,Andrew Mugler
标识
DOI:10.1103/physrevlett.132.098403
摘要
Cells employ control strategies to maintain a stable size. Dividing at a target size (the "sizer" strategy) is thought to produce the tightest size distribution. However, this result follows from phenomenological models that ignore the molecular mechanisms required to implement the strategy. Here we investigate a simple mechanistic model for exponentially growing cells whose division is triggered at a molecular abundance threshold. We find that size noise inherits the molecular noise and is consequently minimized not by the sizer but by the "adder" strategy, where a cell divides after adding a target amount to its birth size. We derive a lower bound on size noise that agrees with publicly available data from six microfluidic studies on Escherichia coli bacteria.
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