心力衰竭
TLR4型
炎症
医学
自噬
上睑下垂
氧化应激
NF-κB
受体
免疫学
内科学
细胞凋亡
生物
炎症体
生物化学
作者
Jiedong Zhou,Hui Lin,Tingting Lv,Jinjin Hao,Hanlin Zhang,Shimin Sun,Juntao Yang,Jufang Chi,Hangyuan Guo
标识
DOI:10.15212/cvia.2022.0020
摘要
Significance: Heart failure, a disease with extremely high incidence, is closely associated with inflammation and oxidative stress. The Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway plays an important role in the occurrence and development of heart failure. Recent advances: Previous studies have shown that TLR4/NF-κB causes heart failure by inducing oxidative stress and inflammation; damaging the endothelia; promoting fibrosis; and inducing myocardial hypertrophy, apoptosis, pyroptosis, and autophagy. Critical issues: Understanding the pathogenesis of heart failure is essential for the treatment of this disease. In this review, we outline the mechanisms underlying TLR4/NF-κB pathway-mediated heart failure and discuss drugs that alleviate heart failure by regulating the TLR4/NF-κB pathway. Future directions: During TLR4/NF-κB overactivation, interventions targeting specific receptor antagonists may effectively alleviate heart failure, thus providing a basis for the development of new anti-heart failure drugs.
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