吲哚嗪
部分
弗里德尔-克拉夫茨反应
化学
表面改性
组合化学
有机化学
催化作用
物理化学
作者
Euijin Jung,Yerin Jeong,Hye-Yeon Kim,Ikyon Kim
出处
期刊:ACS omega
[American Chemical Society]
日期:2023-04-27
卷期号:8 (18): 16131-16144
被引量:3
标识
DOI:10.1021/acsomega.3c00236
摘要
A highly efficient Friedel–Crafts type hydroxyalkylation at the C3 position of indolizines with (hetero)arylglyoxals has been achieved by the action of hexafluoroisopropanol (HFIP) under mild reaction conditions, leading to direct access to a variety of polyfunctionalized indolizines in excellent yields. Installation of more diverse functional groups at the C3 site of indolizine scaffold was realized via further elaboration of the resulting α-hydroxyketone moiety, allowing for expansion of indolizine chemical space.
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