生酮饮食
齿状回
神经发生
海马体
内分泌学
内科学
细胞凋亡
半胱氨酸蛋白酶3
医学
生物
神经科学
癫痫
生物化学
程序性细胞死亡
作者
Irfannuddin Irfannuddin,Siti Fazzaura Putri Sarahdeaz,Krisna Murti,Budi Santoso,Noriyuki Koibuchi
标识
DOI:10.1186/s12576-020-00786-7
摘要
Ketogenic diets (KD) have become popular diet to lose weight. However, the effect of such diets on brain function has not yet been clarified. Thus, we aimed to study the effects of KD on the neurogenesis and apoptosis in the dentate gyrus by assessing the expression of Ki-67 and Caspase-3. Rats (n = 24) were divided into four groups: control (normal diet), ketogenic diet (KD), time-restricted diet (TRD), and the combination of high-fat and time-restricted diet (CD) groups. The expression of Ki-67 in the TRD and CD groups was higher compared to others (P < 0.05), whereas no such difference was observed in the KD group. The number of Capase-3-positive cells decreased significantly in the TRD group (P < 0.05), but such decrease was not observed in the CD group. These results indicate that, although KD could be effective in reducing the body weight, possible adverse effect in the brain cannot be ignored.
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