Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis

Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp³) acids with labeled CO₂. Substrates that are not compatible with transition-metal-catalyzed degradation-reconstruction approaches or prone to thermally induced reversible decarboxylation undergo isotopic incorporation at room temperature in short reaction times. The radiolabeling of drug molecules and precursors with [¹¹C]CO₂ is demonstrated.