Fungal Polysaccharides Promote Protective Immunity

Fungal pathogens represent a rising threat against immunocompromised patients. By using Aspergillus fumigatus, Briard et al. showed that the cell wall galactosaminogalactan (GAG) triggers macrophage inflammasome activation, promoting protective immunity. This provides new insights into the role of GAG in host–pathogen interactions and also perspectives for developing GAG-based anti-inflammatory therapeutics. Fungal pathogens represent a rising threat against immunocompromised patients. By using Aspergillus fumigatus, Briard et al. showed that the cell wall galactosaminogalactan (GAG) triggers macrophage inflammasome activation, promoting protective immunity. This provides new insights into the role of GAG in host–pathogen interactions and also perspectives for developing GAG-based anti-inflammatory therapeutics.