医学
放射性肠炎
粘膜炎
放射治疗
临床试验
入射(几何)
疾病
随机对照试验
重症监护医学
内科学
肿瘤科
胃肠病学
光学
物理
作者
Lina Lu,Wenjun Li,Lihua Chen,Qiong Su,Yanbin Wang,Zhong Guo,Yuehui Lu,Bin Liu,Qingwei Song
出处
期刊:Future Oncology
[Future Medicine]
日期:2019-12-01
卷期号:15 (35): 4105-4118
被引量:44
标识
DOI:10.2217/fon-2019-0416
摘要
Aim: To systematically review the prophylactic and therapeutic interventions for reducing the incidence or severity of intestinal symptoms among cancer patients receiving radiotherapy. Materials & methods: A literature search was conducted in the PubMed database using various search terms, including ‘radiation enteritis’, ‘radiation enteropathy’, ‘radiation-induced intestinal disease’, ‘radiation-induced intestinal damage’ and ‘radiation mucositis’. The search was limited to in vivo studies, clinical trials and meta-analyses published in English with no limitation on publication date. Other relevant literature was identified based on the reference lists of selected studies. Results: The pathogenesis of acute and chronic radiation-induced intestinal damage as well as the prevention and treatment approaches were reviewed. Conclusion: There is inadequate evidence to strongly support the use of a particular strategy to reduce radiation-induced intestinal damage. More high-quality randomized controlled trials are required for interventions with limited evidence suggestive of potential benefits.
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