Syntheses of polyethylene glycol (PEG) with different functional groups at each end. I. Preparation of monotrityl PEG using polyvinyl alcohol (PVA) matrix

Abstract The syntheses and separation of monotrityl PEGs with molecular weights in the range of 400–6000 were successful using PVA as matrix. The yield of monotrityl PEG is strongly dependent on the initial mole ratio of PEG—trityl chloride. It is observed that satisfactory results can only be obtained in the range of 1 : 1.7 to 1 : 2.4 (mole number of PEG/mole number of trityl chloride). The effect of reaction conditions on monosubstitution is discussed. © 1992 John Wiley & Sons, Inc.