化学
非对映体
三氟甲基
硅烷化
加合物
激进的
烯醇
药物化学
苯乙烯
催化作用
有机化学
共聚物
聚合物
烷基
作者
Takashi Okano,Hirokazu Sugiura,Masataka Fumoto,Hiroyoshi Matsubara,Takahiro Kusukawa,Makoto Fujita
标识
DOI:10.1016/s0022-1139(02)00002-7
摘要
Relatively unreactive aryltrifluoroethyl bromides were reacted with 1-octene in the presence of CuCl and 2,2′-bipyridyl at high temperatures. Trifluoromethylated benzyl radical was generated, and a diastereomer mixture of radical adducts was obtained with a (60–70):(40–30) diastereomer ratio. Ph3SnH reduction of the adducts gave the corresponding hydrocarbons with an isolated trifluoromethyl group. The reactions with styrene or aromatic and aliphatic silyl enol ethers led to the formation of trifluorodiphenylbutene and β-trifluoromethylated ketones, respectively.
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