阿米洛利
胃窦
甲基亚硝基胍
胃粘膜
胃
内科学
医学
抗癌原
内分泌学
致癌物
胃肠病学
癌变
病理
癌症
化学
钠
生物化学
突变体
有机化学
基因
作者
Masaharu Tatsuta,Hiroyasu Iishi,Miyako Baba,Hiroyuki Uehara,Akihiko Nakaizumi,Hirokazu Taniguchi
摘要
The effects of amiloride on the incidence and histological types of gastric cancers in Wistar rats induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and on the labelling index and proliferative fraction of gastric mucosa were investigated. After oral treatment with MNNG for 25 weeks, rats received s.c. injections of amiloride (0.25 mg kg-1 or 5.0 mg kg-1 body weight) in depot form every other day until the end of the experiment. Prolonged administration of 5.0 mg kg-1, but not 2.5 mg kg-1 of amiloride significantly decreased the incidence of gastric cancers in Week 52. However, it did not influence the histological features of the gastric cancers. It also significantly decreased the labelling index and proliferative fraction of the antral mucosa. These findings indicate that amiloride inhibits the development of gastric cancers, and that its effect may be related to its effect in decreasing cell proliferation of the antral mucosa.
科研通智能强力驱动
Strongly Powered by AbleSci AI