运动性
细胞生物学
细胞外
肌动蛋白
埃兹林
岩石1
细胞骨架
CDC42型
罗亚
细胞迁移
肌动蛋白细胞骨架
生物
Rac-GTP结合蛋白
细胞外基质
细胞
焦点粘着
蛋白质水解
信号转导
RAC1
生物化学
酶
作者
Erik Sahai,Christopher J. Marshall
摘要
Rho family GTPases regulate the cytoskeleton and cell migration and are frequently overexpressed in tumours. Here, we identify two modes of tumour-cell motility in 3D matrices that involve different usage of Rho signalling. Rho signalling through ROCK promotes a rounded bleb-associated mode of motility that does not require pericellular proteolysis. This form of motility requires ezrin, which is localized in the direction of cell movement. In contrast, elongated cell motility is associated with Rac-dependent F-actin-rich protrusions and does not require Rho, ROCK or ezrin function. Combined blockade of extracellular proteases and ROCK negates the ability of tumour cells to switch between modes of motility and synergises to prevent tumour cell invasion.
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