Severe Extrapyramidal Symptoms in a 3-Year-Old Boy After Accidental Ingestion of the New Antipsychotic Drug Aripiprazole

To the Editor .— Aripiprazole is a new type of antipsychotic medication exhibiting high-affinity partial agonist activity at D2-dopamine receptors.1,2 When used in adults for the treatment of schizophrenia and schizoaffective disorder, aripiprazole has been associated with extrapyramidal symptoms (EPS) at a rate similar to that of placebo.3 Although it has been used in children, aripiprazole's safety profile in pediatric age groups is unknown.2,4 We report a case of severe EPS in a 3-year-old boy after accidental ingestion of a single dose of <15 …