烯丙基重排
催化作用
化学
组合化学
卤化物
镍
偶联反应
烷基
分子
键裂
三氟甲基
药物化学
有机化学
作者
Yun Lan,Feiyan Yang,Chuan Wang
标识
DOI:10.1021/acscatal.8b02784
摘要
In this protocol, we report an allylic defluorinative reductive cross-coupling reaction for C–C bond formation. Under the Ni-catalysis the challenging C(sp3)–F bond cleavage of trifluoromethyl-substituted alkenes was achieved with easily accessible primary, secondary and tertiary alkyl halides as the coupling partners and Zn-powder as reducing agent. This process provides an efficient and convenient entry to gem-difluoroalkenes bearing various sensitive functional groups under mild reaction conditions. Moreover, this method proves to be suitable for late-stage functionalization of multifunctional complex molecules.
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