淋巴管新生
血管内皮生长因子C
淋巴系统
淋巴管内皮
癌症研究
血管内皮生长因子
转移
医学
细胞生物学
淋巴管
生物
血管内皮生长因子A
免疫学
癌症
血管内皮生长因子受体
内科学
作者
Ming-Chuan Hsu,Mei-Ren Pan,Wen‐Chun Hung
出处
期刊:Cells
[MDPI AG]
日期:2019-03-21
卷期号:8 (3): 270-270
被引量:37
摘要
: Vascular endothelial growth factor receptor 3 (VEGFR3) has been known for its involvement in tumor-associated lymphangiogenesis and lymphatic metastasis. The VEGFR3 signaling is stimulated by its main cognate ligand, vascular endothelial growth factor C (VEGF-C), which in turn promotes tumor progression. Activation of VEGF-C/VEGFR3 signaling in lymphatic endothelial cells (LECs) was shown to enhance the proliferation of LECs and the formation of lymphatic vessels, leading to increased lymphatic metastasis of tumor cells. In the past decade, the expression and pathological roles of VEGFR3 in tumor cells have been described. Moreover, the VEGF-C/VEGFR3 axis has been implicated in regulating immune tolerance and suppression. Therefore, the inhibition of the VEGF-C/VEGFR3 axis has emerged as an important therapeutic strategy for the treatment of cancer. In this review, we discuss the current findings related to VEGF-C/VEGFR3 signaling in cancer progression and recent advances in the development of therapeutic drugs targeting VEGF-C/VEGFR3.
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