医学
创伤性脑损伤
临床试验
重症监护医学
精神科
病理
作者
Brian Appavu,Stephen T. Foldes,P. David Adelson
出处
期刊:Journal of neurosurgery
[Journal of Neurosurgery Publishing Group]
日期:2019-06-01
卷期号:23 (6): 661-669
被引量:21
标识
DOI:10.3171/2019.2.peds18384
摘要
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children both in the United States and throughout the world. Despite valiant efforts and multiple clinical trials completed over the last few decades, there are no high-level recommendations for pediatric TBI available in current guidelines. In this review, the authors explore key findings from the major pediatric clinical trials in children with TBI that have shaped present-day recommendations and the insights gained from them. The authors also offer a perspective on potential efforts to improve the efficacy of future clinical trials in children following TBI.
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