化学
电泳剂
皮兰
环加成
催化作用
组合化学
衍生工具(金融)
药物化学
材料化学
氯化物
立体化学
有机化学
反应机理
绿色化学
金融经济学
经济
作者
Artur Przydacz,Aleksandra Topolska,Anna Skrzyńska,Łukasz Albrecht
标识
DOI:10.1002/adsc.202101338
摘要
Abstract A dearomative formal (4+2)‐cycloaddition reaction between 2‐substituted 3‐furaldehydes derivatives and isatins or α,α,α‐trifluoroacetophenones as electrophiles has been established under NHC‐catalysis. This approach utilizes the process of hydrogen chloride 1,4‐elimination leading to a highly reactive NHC‐bound heterocyclic o ‐QDM intermediates derived from 3‐furaldehydes, which play a key role in the process. By using this strategy, a series of structurally diverse 6,7‐dihydro‐4 H ‐furo[3,2‐ c ]pyran‐4‐ones was prepared in 41–85% yields. In addition, the potential of the obtained (4+2)‐cycloadducts has been confirmed in the synthesis of interesting class of spirooxindole derivative containing 6,7‐dihydro‐4 H ‐furo[3,2‐ c ]pyran scaffold. magnified image
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