自愈水凝胶
明胶
材料科学
脚手架
壳聚糖
组织工程
细胞外基质
海藻酸钠
化学工程
生物相容性材料
细胞毒性
多糖
三维细胞培养
纳米技术
生物医学工程
细胞
高分子化学
钠
化学
有机化学
体外
生物化学
医学
冶金
工程类
作者
Etienne Twizeyimana,Shuang Zhang,Jean Felix Mukerabigwi,Zhishen Ge
标识
DOI:10.1007/s13233-022-0030-z
摘要
Advances in designing smart hydrogels with the structures and properties similar to the interior of extracellular matrix have aroused the interest of researchers as promising cell support scaffolds in the field of tissue engineering. In this study, a novel hydrogel system is developed from natural polysaccharides that are sodium alginate, gelatin and carboxymethyl chitosan through Schiff base cross-linking mechanism. By mixing these three components, the hydrogel system with tunable strength and gelation time was obtained and abbreviated as oxACG hydrogel. Moreover, the obtained hydrogels are biocompatible and can sustain the growth and proliferation of Hela cells after 24 h incubation. The experimental results show that the hydrogel possesses a relatively short gelation time that is around 3 min, high gel strength and negligible cell cytotoxicity. The oxACG hydrogel composite exhibited desirable properties, and they can be used as high-performance multifunctional injectable hydrogels in cell therapy.
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