疾病
神经科学
线粒体DNA
线粒体
电池类型
细胞
生物
神经退行性变
小胶质细胞
粒线体疾病
帕金森病
医学
遗传学
免疫学
病理
炎症
基因
作者
Laura J. Bailey,Joanna L. Elson,Ilse S. Pienaar
出处
期刊:Methods in molecular biology
日期:2021-01-01
卷期号:: 299-329
被引量:1
标识
DOI:10.1007/978-1-0716-1270-5_19
摘要
In light of accumulating evidence suggestive of cell type-specific vulnerabilities as a result of normal aging processes that adversely affect the brain, as well as age-related neurodegenerative disorders such as Parkinson’s disease (PD), the current chapter highlights how we study mitochondrial DNA (mtDNA) changes at a single-cell level. In particular, we comment on increasing questioning of the narrow neurocentric view of such pathologies, where microglia and astrocytes have traditionally been considered bystanders rather than players in related pathological processes. Here we review the contribution made by single-cell mtDNA alterations towards neuronal vulnerability seen in neurodegenerative disorders, focusing on PD as a prominent example. In addition, we give an overview of methodologies that support such experimental investigations. In considering the significant advances that have been made in recent times for developing mitochondria-specific therapies, investigations to account for cell type-specific mitochondrial patterns and how these are altered by disease hold promise for delivering more effective disease-modifying therapeutics.
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