化学
可操作性
衍生工具(金融)
组合化学
钥匙(锁)
过程(计算)
放热反应
生化工程
工艺工程
纳米技术
有机化学
计算机科学
材料科学
经济
工程类
软件工程
操作系统
金融经济学
计算机安全
作者
Zhongqing Wang,Guobin Xu,Huixiong Lü,Shuming Wu,Shouzhu Liao,Yanqing Hu,Jidi Lin,Zijian Liu
出处
期刊:Tetrahedron
[Elsevier]
日期:2021-11-01
卷期号:101: 132503-132503
被引量:1
标识
DOI:10.1016/j.tet.2021.132503
摘要
An alternative synthetic route towards the key intermediate of ritlecitinib has been developed. Stereochemistry of intermediate 10 was introduced based on chiral pool strategy by employing d-pyroglutamate derivative 20 as starting material and chiral salt resolution strategy by using safer resolving agents without exothermic risk. The economical cost was lowered by avoiding noble metals catalyzed hydrogenation while maintaining a high-quality delivery of key intermediate 10 with excellent selectivity and purity. From process operability perspectives, all chromatographic purifications were eliminated and the process is readily scalable.
科研通智能强力驱动
Strongly Powered by AbleSci AI