免疫学
银屑病
白细胞介素17
细胞因子
医学
白细胞介素23
肿瘤坏死因子α
炎症
促炎细胞因子
白细胞介素
RAR相关孤儿受体γ
白细胞介素10
白细胞介素6
生物
作者
Dan Yue,Yong You,Xiaoqing Zhang,Biao Wang,Xiao Wang,Ruiqun Qi,Fan Yang,Xin Meng,Yasunobu Yoshikai,Yuanyuan Wang,Xun Sun
标识
DOI:10.1016/j.jaut.2019.04.009
摘要
Abstract Psoriasis is a common, autoimmune, chronic inflammatory skin disease. It has been demonstrated that cutaneous T17 cells play an important pro-inflammatory role in the pathogenesis of psoriasis, through the production of various Th17-related cytokines. Our previous studies have demonstrated that CD30L/CD30 signal plays a pivotal role in the differentiation of CD4+ Th17 cells and Vγ6+γδ T17 cells in the gut-associated lymphoid tissues of mouse. However, its effect on the pathogenesis of psoriasis is unknown. Here, we fully prove that CD30L/CD30 signaling plays a novel protective role in the development of psoriasis in mice, through selective inhibition of CCR6 expression and Th17-related cytokine synthesis in the Vγ4+γδ T17 cell subset. Meanwhile, treatment with agonistic anti-CD30 mAb had a significant therapeutic effect on our psoriasis mouse model. Therefore, the CD30L/CD30 signaling pathway is an ideal target for antibody therapy, which may become a new approach for the immunobiological treatment of psoriasis.
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