线粒体
线粒体DNA
神经退行性变
疾病
药物开发
线粒体融合
生物信息学
医学
核基因
粒线体疾病
药理学
药品
生物
神经科学
基因
计算生物学
遗传学
病理
作者
Michael P. Murphy,Richard C. Hartley
摘要
Although the development of mitochondrial therapies has largely focused on diseases caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial proteins, it has been found that mitochondrial dysfunction also contributes to the pathology of many common disorders, including neurodegeneration, metabolic disease, heart failure, ischaemia-reperfusion injury and protozoal infections. Mitochondria therefore represent an important drug target for these highly prevalent diseases. Several strategies aimed at therapeutically restoring mitochondrial function are emerging, and a small number of agents have entered clinical trials. This Review discusses the opportunities and challenges faced for the further development of mitochondrial pharmacology for common pathologies.
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