随机对照试验
医学
生活质量(医疗保健)
物理疗法
人口
笑声
临床试验
临床终点
干预(咨询)
外科
心理学
内科学
精神科
护理部
环境卫生
神经科学
作者
Toshitaka Morishima,Isao Miyashiro,Norimitsu Inoue,Mitsuko Kitasaka,Takashi Akazawa,Akemi Higeno,Atsushi Idota,Akira Sato,Tetsuya Ohira,Masato Sakon,Nariaki Matsuura
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2019-06-27
卷期号:14 (6): e0219065-e0219065
被引量:29
标识
DOI:10.1371/journal.pone.0219065
摘要
Background Few randomized controlled trials have assessed the effects of laughter therapy on health-related quality of life (QOL) in cancer patients. This study aimed to evaluate these effects as an exploratory endpoint in cancer patients as part of a randomized controlled trial conducted at a single institution in Japan. Methods The Initiative On Smile And CAncer (iOSACA) study was an open-label randomized controlled trial conducted in 2017 in which participants aged 40–64 years with cancer were randomly assigned to either an intervention group (laughter therapy) or control group (no laughter therapy). Each participant in the intervention group underwent a laughter therapy session once every two weeks for seven weeks (total of four sessions). Each session involved a laughter yoga routine followed by Rakugo or Manzai traditional Japanese verbal comedy performances. We assessed QOL as a secondary endpoint in this intention-to-treat population using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). The questionnaire was completed at baseline (Week 0) and at Weeks 3 and 7. Mixed-effects models for repeated measures were developed to compare time-dependent changes in each QOL domain from baseline between the intervention and control groups. Results Four participants retracted consent and one participant was retrospectively excluded from analysis due to unmet inclusion criteria. The analysis was conducted using 56 participants, with 26 in the intervention group and 30 in the control group. Questionnaire completion rates were high (>90%), with similar QOL scores reported at baseline in both groups. The mixed-effects models showed that the intervention group had significantly better cognitive function and less pain than the control group for a short period. Conclusion Laughter therapy may represent a beneficial, noninvasive complementary intervention in the clinical setting. Further studies are needed to verify the hypotheses generated from this exploratory study.
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