Hyperglycaemic control of histone code in metabolic inflammation and microvascular complications

Epigenetic mechanisms regulate development of diabetic vascular complications and metabolic memory. Histone code is an essential mechanism of epigenetic memory affected by diabetic conditions. Monocytes (Mo) and macrophages (MF) are key innate immune cells that control inflammatory reactions leading to vascular complications. However, the mechanisms of hyperglycemia-induced epigenetic changes in human macrophages are not known.