Impact of PathogenicFBN1Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome

BACKGROUND: genotype and severe aortopathy (aortic root replacement, type A dissections, and related death). METHODS: genotype on severe aortic events (aortic root replacement, type A dissections, and related death). RESULTS: <0.001). CONCLUSIONS: DN-CD+HI patients should be monitored more carefully than DN-nonCD patients for rapid development of aortic root aneurysms.