Experiment control test of the using Panaxsaponin Rgl and Rbl on hepatic fibrosis

Objective:To investigate the effect of Panaxsaponic and Rbl on hepatic fibrosis, which are two of the main ingredients of Panax Notoginsenosides.Methods: The rats models of hepatic fibrosis were made by using 50% CCl4, at the same time, the Panaxsaponic Rbl on different doses and Panax Notoginsenosides were given by hypodermical injection. At the end of the treatment, the levels of precollagen Ⅲ(PCⅢ),hyaluronic acid(HA) and laminin(LN)in the blood seum, and the pathological change of hepatic tissue were tested.Results: Panax Notoginsenosides can improve hepatic function and degrade the levels of PCⅢ、HA、LN on the rats models, and had the same deletable effect on the pathological change. While Panaxsaponin Rbl can not improve hepatic fibrosis, moreover it can damage the hepatic function.Conclusion:Panaxsaponin Rbl is not effective on hepatic fibrosis. Panaxsaponic Rbl is not one of the effective ingredients of Panax Notoginsenosides which can be used in hepatic fibrosis.