自愈水凝胶
丝素
单宁酸
壳聚糖
伤口愈合
光致聚合物
化学
材料科学
丝绸
高分子化学
复合材料
聚合物
外科
有机化学
聚合
医学
作者
Xi He,Xuezhe Liu,Yang Jin,Haibo Du,Ningwen Chai,Sha Zhou,Meng Geng,Xiaojun Zhou,Chuanglong He
标识
DOI:10.1016/j.carbpol.2020.116689
摘要
Natural polymeric hydrogel featuring multifunctional properties is more attractive as wound dressing. Herein, Tannic acid (TA)-reinforced methacrylated chitosan (CSMA)/methacrylated silk fibroin (SFMA) hydrogels were fabricated by two-step method of photopolymerization and TA solution incubating treatment. The TA in hydrogels not only served as second crosslinker improving the mechanical performance of up to a 5-fold increase (5 % TA treatment) than the pristine one, but also as functional molecule that endowed the hydrogels with enhanced adhesiveness and antioxidative properties. Besides, the introduction of TA into hydrogels further improved the antimicrobial activities against both Escherichia coli (E. coli) and Staphylococcus Aureus (S. aureus), as well as the cytocompatibility on fibroblasts. Moreover, it was demonstrated that the TA-treated CSMA/SFMA hydrogels could significantly promote wound healing in a full-thickness skin defect model. Collectively, these results showed that TA-reinforced CSMA/SFMA hydrogels could be a promising candidate as wound dressing.
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