生物
基因敲除
癌症研究
RNA结合蛋白
细胞周期
信使核糖核酸
细胞周期蛋白D1
肿瘤进展
细胞周期蛋白D
细胞周期蛋白
细胞生长
细胞周期蛋白B1
分子生物学
癌变
核糖核酸
细胞
癌症
基因
细胞周期蛋白依赖激酶1
生物化学
遗传学
作者
Huan Feng,Juan Liu,Yangyang Qiu,Yao Liu,Hexige Saiyin,Xiao Liang,Fuqiang Zheng,Ying Wang,Deke Jiang,Ying Wang,Yu Liu,Wei Su,Suqin Shen,Jiaxue Wu
出处
期刊:Oncogene
[Springer Nature]
日期:2020-07-06
卷期号:39 (33): 5495-5506
被引量:18
标识
DOI:10.1038/s41388-020-1380-7
摘要
RNA-binding proteins play key roles in the posttranscriptional regulation of mRNA during cancer progression. Here, we show that RNA-binding motif protein 43 (RBM43) is significantly downregulated in human tumors, and its low expression is correlated with poor prognosis in patients with HCC. Overexpression of RBM43 suppressed cell proliferation in culture and resulted in the growth arrest of tumor xenografts, whereas downregulating RBM43 played an opposite role. We have also demonstrated that overexpression or knockdown of RBM43 affects the cell-cycle progression of liver cancer cells. Mechanistically, RBM43 directly associated with the 3'UTR of Cyclin B1 mRNA and regulated its expression. Moreover, loss of Rbm43 in mice promoted liver carcinogenesis and HCC development after diethylnitrosamine (DEN)-carbon tetrachloride (CCl4) treatment. Taken together, our data indicate that RBM43 is a tumor suppressor that controls the cell cycle through modulation of Cyclin B1 expression, providing evidence that RBM43 is particularly important in HCC.
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