医学
感染性休克
败血症
弥漫性血管内凝血
氨甲环酸
凝血病
重症监护医学
内科学
器官功能障碍
外科
失血
作者
Ahmed El-Nawawy,Mohamed Elshinawy,Doaa Khater,Azza A Moustafa,Nehad Hassanein,Yasser Wali,Hanan Nazir
出处
期刊:Pediatric Critical Care Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2020-10-12
卷期号:22 (3): e168-e177
被引量:9
标识
DOI:10.1097/pcc.0000000000002578
摘要
Objectives: Evaluation of the outcome of early hemostatic management of disseminated intravascular coagulopathy in patients with severe sepsis/septic shock admitted to PICU, before the development of clinically overt disseminated intravascular coagulopathy. Design: Prospective interventional, open label randomized controlled clinical trial. Setting: PICU at Alexandria University Children’s Hospital. Patients: The study included 80 patients with proven severe sepsis/septic shock in nonovert disseminated intravascular coagulopathy stage. They were randomly assigned into two groups (group 1 and group 2). Interventions: Specific intervention was applied for group 1 (plasma transfusion, low-dose unfractionated heparin, and tranexamic acid). Measurements: All patients had assessment of Pediatric Index of Mortality 2 score, Pediatric Logistic Organ Dysfunction score, inotropic score, routine laboratory, and hemostatic tests including fibrin degradation products and d -dimers. Disseminated intravascular coagulopathy risk assessment scores were calculated on daily basis. Results: Mortality rate was significantly higher in group 2. Progression to overt disseminated intravascular coagulopathy was significantly more common among group 2 patients than group 1 (45% and 10%, respectively) ( p < 0.0001). Disseminated intravascular coagulopathyRisk Assessment Scores were significantly higher on the second and fifth days among group 2 patients. The initial specific hemostatic intervention was the only significant predictor of survival and prevention of progression to overt disseminated intravascular coagulopathy. Conclusions: Our results suggest that early use of a combination of fresh frozen plasma transfusion, low-dose heparin, and tranexamic acid in children with severe sepsis/septic shock in the “window of opportunity” before the development of overt disseminated intravascular coagulopathy stage was associated with better outcome for survival and prevention of progression to overt disseminated intravascular coagulopathy, with no increase in bleeding risk. Larger multicenter studies are needed to further prove this practice.
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