吗啡
医学
活检
病理
局限性硬皮病
皮肤活检
皮肤病科
皮肤病理学
回顾性队列研究
组织病理学
硬化性苔藓
作者
Yvonne E. Chiu,Cynthia Y. Abban,Kathryn Konicke,Annette D. Segura,Olayemi Sokumbi
出处
期刊:American Journal of Dermatopathology
[Ovid Technologies (Wolters Kluwer)]
日期:2020-05-01
卷期号:43 (1): 1-8
被引量:15
标识
DOI:10.1097/dad.0000000000001662
摘要
Abstract: Morphea is an autoimmune skin disease with protean clinical manifestations. Histologic features are similarly variable, and skin biopsies may be nondiagnostic. A single-institution retrospective cohort study was conducted. Morphea patients who had a biopsy in 2005–2015 were included, and a histopathological review was conducted by 2 pathologists. There were 51 biopsy specimens from 40 subjects. The most common histologic features were dermal sclerosis (90%), dermal thickening (78%), collagen homogenization (86%), a superficial and deep infiltrate (76%), a moderate–abundant inflammatory infiltrate (73%), and periadnexal fat loss/decreased skin appendages (71%). Twenty-four specimens were not diagnostic of morphea. In these specimens, the main clues to diagnosis included the presence of dermal sclerosis (79%), subtle collagen homogenization (75%), dermal thickening (58%), moderate-to-abundant plasma cells (50%), and perineural inflammation (50%). There were no statistically significant differences between active and inactive lesions, nor untreated and treated lesions. The histopathologic features of morphea are variable and a high proportion of biopsies are not diagnostic. Clinicians and pathologists should have a high degree of suspicion to correctly make the diagnosis of morphea.
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