弹性蛋白
原弹性蛋白
纤维蛋白
老化
细胞外基质
化学
弹性纤维
人体皮肤
染色
皮肤老化
细胞生物学
分子生物学
生物化学
解剖
病理
生物
医学
皮肤病科
遗传学
作者
Dianne Rossetti,M. Kielmanowicz,S. Vigodman,Yaping Hu,N. Chen,Alex Nkengne,Thierry Oddos,David Fischer,Miri Seiberg,Connie B. Lin
标识
DOI:10.1111/j.1468-2494.2010.00588.x
摘要
Synopsis Dermal elastic fibres are extracellular matrix protein complexes produced by fibroblasts and involved in skin elasticity. Elastin fibres decrease with age as a result of reduced synthesis and increased degradation, resulting in skin sagging and reduced skin elasticity. In this study, we show that retinol (ROL), known to enhance dermal collagen production, is also enhancing elastin fibre formation. ROL induced elastin gene expression and elastin fibre formation in cultured human dermal fibroblasts. Topical treatment of cultured human skin explants with a low dose (0.04%) of ROL increased mRNA and protein levels of tropoelastin and of fibrillin‐1, an elastin accessory protein, as documented by QPCR and immunohistochemistry staining. Luna staining confirmed the increased elastin fibre network in the ROL‐treated skin explants, as compared with untreated controls. These data demonstrate that ROL exerts its anti‐ageing benefits not only via enhanced epidermal proliferation and increased collagen production, but also through an increase in elastin production and assembly.
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