大流行
连接体
前瞻性队列研究
医学
精神科
压力源
2019年冠状病毒病(COVID-19)
意识的神经相关物
心理学
临床心理学
内科学
功能连接
认知
疾病
神经科学
传染病(医学专业)
作者
Zhiyi Chen,Pan Feng,Benjamin Becker,Ting Xu,Matthew R. Nassar,Fuschia M. Sirois,Bernhard Hommel,Chenyan Zhang,Qinghua He,Jiang Qiu,Li He,Xu Lei,Hong Chen,Tingyong Feng
标识
DOI:10.1016/j.ynstr.2021.100378
摘要
The novel coronavirus (COVID-19) pandemic has affected humans worldwide and led to unprecedented stress and mortality. Detrimental effects of the pandemic on mental health, including risk of post-traumatic stress disorder (PTSD), have become an increasing concern. The identification of prospective neurobiological vulnerability markers for developing PTSD symptom during the pandemic is thus of high importance.Before the COVID-19 outbreak (September 20, 2019-January 11, 2020), some healthy participants underwent resting-state functional connectivity MRI (rs-fcMRI) acquisition. We assessed the PTSD symptomology of these individuals during the peak of COVID-19 pandemic (February 21, 2020-February 28, 2020) in China. This pseudo-prospective cohort design allowed us to test whether the pre-pandemic neural connectome status could predict the risk of developing PTSD symptom during the pandemic.A total of 5.60% of participants (n = 42) were identified as being high-risk to develop PTSD symptom and 12.00% (n = 90) exhibited critical levels of PTSD symptoms during the COVID-19 pandemic. Pre-pandemic measures of functional connectivity (the neural connectome) prospectively classified those with heightened risk to develop PTSD symptom from matched controls (Accuracy = 76.19%, Sensitivity = 80.95%, Specificity = 71.43%). The trained classifier generalized to an independent sample. Continuous prediction models revealed that the same connectome could accurately predict the severity of PTSD symptoms within individuals (r2 = 0.31p<.0).This study confirms COVID-19 break as a crucial stressor to bring risks developing PTSD symptom and demonstrates that brain functional markers can prospectively identify individuals at risk to develop PTSD symptom.
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