前药
医学
药理学
心肌肥大
活性氧
机制(生物学)
硫化氢
化学
肌肉肥大
心脏病学
生物化学
认识论
哲学
有机化学
硫黄
作者
Peng Wen,Weiwei Guo,Yapeng Zheng
标识
DOI:10.2174/1568026621666210831163817
摘要
Hydrogen sulfide (H2S), as one of the endogenous gasotransmitters, has shown great potential in treating cardiovascular diseases (CVDs). H2S plays a protective role in CVDs by removing reactive oxygen species (ROS), promoting vasodilation, inhibiting myocardial hypertrophy, preventing thrombosis, and protecting mitochondria. However, there still exist some problems for H2S as drugs such as challenging delivery, uncontrollable release rate, and other drug developability issues. Addressing these problems, the prodrug strategy shows great potential. Therefore, a key issue on the H2S-based therapeutics is developing appropriate H2S prodrugs. In this review, we mainly discussed the mechanism of H2S against CVDs and reviewed the cardiovascular effects of current H2S prodrugs.
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