Recent Development of Hydrogen Sulfide Therapeutics in the Treatment of Cardiovascular Diseases

Hydrogen sulfide (H 2 S), as one of the endogenous gasotransmitters, has shown great potential in treating cardiovascular diseases (CVDs). H 2 S plays a protective role in CVDs by removing reactive oxygen species (ROS), promoting vasodilation, inhibiting myocardial hypertrophy, preventing thrombosis, and protecting mitochondria. However, there still exist some problems for H 2 S as drugs such as challenging delivery, uncontrollable release rate, and other drug developability issues. Addressing these problems, the prodrug strategy shows great potential. Therefore, a key issue on the H 2 S-based therapeutics is developing appropriate H2S prodrugs. In this review, we mainly discussed the mechanism of H 2 S against CVDs and reviewed the cardiovascular effects of current H 2 S prodrugs.