再生(生物学)
音猬因子
Wnt信号通路
生物
小RNA
非编码RNA
刺猬信号通路
细胞生物学
毛囊
核糖核酸
神经科学
生物信息学
信号转导
遗传学
基因
作者
Min Yang,Tingting Weng,Wei Zhang,Manjia Zhang,Xin He,Chunmao Han,Xingang Wang
标识
DOI:10.3389/fcell.2021.720879
摘要
Alopecia is a common problem that affects almost every age group and is considered to be an issue for cosmetic or psychiatric reasons. The loss of hair follicles (HFs) and hair caused by alopecia impairs self-esteem, thermoregulation, tactile sensation and protection from ultraviolet light. One strategy to solve this problem is HF regeneration. Many signalling pathways and molecules participate in the morphology and regeneration of HF, such as Wnt/β-catenin, Sonic hedgehog, bone morphogenetic protein and Notch. Non-coding RNAs (ncRNAs), especially microRNAs and long ncRNAs, have significant modulatory roles in HF development and regeneration via regulation of these signalling pathways. This review provides a comprehensive overview of the status and future prospects of ncRNAs in HF regeneration and could prompt novel ncRNA-based therapeutic strategies.
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