Plant responses to multifactorial stress combination

Summary Human activity is causing a global change in plant environment that includes a significant increase in the number and intensity of different stress factors. These include combinations of multiple abiotic and biotic stressors that simultaneously or sequentially impact plants and microbiomes, causing a significant decrease in plant growth, yield and overall health. It was recently found that with the increasing number and complexity of stressors simultaneously impacting a plant, plant growth and survival decline dramatically, even if the level of each individual stress, involved in such ‘multifactorial stress combination’, is low enough not to have a significant effect. Here we highlight this new concept of multifactorial stress combination and discuss its importance for our efforts to develop climate change‐resilient crops.