体内分布
嵌合抗原受体
细胞疗法
癌症研究
临床试验
食品药品监督管理局
细胞
T细胞
体内
药理学
医学
化学
免疫学
免疫系统
病理
生物
生物化学
生物技术
作者
Louise Kiru,Aimen Zlitni,Aidan M. Tousley,Guillermo Nicolás Dalton,Wenqi Wu,Famyrah Lafortune,Anna Liu,Kristen Cunanan,Hossein Nejadnik,Todd Sulchek,Michael E. Moseley,Robbie G. Majzner,Heike E. Daldrup-Link
标识
DOI:10.1073/pnas.2102363119
摘要
Significance Chimeric antigen receptor (CAR) T-cell therapy is approved by the US Food and Drug Administration (FDA) for the treatment of B-cell acute lymphoblastic leukemia. Efforts are now underway to evaluate the efficacy of CAR T-cell therapy in solid tumors. However, a key limitation in the advancement of T-cell therapy is the lack of information on the biodistribution of the T cells in patients. Therefore, there is a need for the identification of translatable methods for tracking the therapeutic T cells noninvasively. We describe the mechanical labeling of CAR T cells with an FDA-approved iron oxide nanoparticle to demonstrate the noninvasive and multimodal imaging of the CAR T cells. This method may be utilized for monitoring T cells in clinical trials.
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