曲率
细胞生物学
生物物理学
膜曲率
音调
细胞骨架
肌动蛋白
生物
肿胀 的
形态发生
肌动蛋白细胞骨架
机械转化
张力(地质)
材料科学
细胞
膜
几何学
生物化学
脂质双层
复合材料
数学
极限抗拉强度
基因
作者
Caterina Tomba,Valeriy Luchnikov,Luca Barberi,Carles Blanch-Mercader,Aurélien Roux
标识
DOI:10.1016/j.devcel.2022.04.017
摘要
Summary
Generation of tissue curvature is essential to morphogenesis. However, how cells adapt to changing curvature is still unknown because tools to dynamically control curvature in vitro are lacking. Here, we developed self-rolling substrates to study how flat epithelial cell monolayers adapt to a rapid anisotropic change of curvature. We show that the primary response is an active and transient osmotic swelling of cells. This cell volume increase is not observed on inducible wrinkled substrates, where concave and convex regions alternate each other over short distances; and this finding identifies swelling as a collective response to changes of curvature with a persistent sign over large distances. It is triggered by a drop in membrane tension and actin depolymerization, which is perceived by cells as a hypertonic shock. Osmotic swelling restores tension while actin reorganizes, probably to comply with curvature. Thus, epithelia are unique materials that transiently and actively swell while adapting to large curvature induction.
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