化学
诺司卡平
亚胺离子
亚胺
胺气处理
加合物
乙醛
组合化学
生物碱
有机化学
离子
催化作用
乙醇
作者
Manuel Soriano,Nagula Shankaraiah,Leonardo S. Santos
标识
DOI:10.1016/j.tetlet.2010.01.104
摘要
A concise diastereotioselective strategy for the synthesis of noscapine, bicuculline, and egenine (1a–c), as well as capnoidine and corytensine (2a,b), was developed using diastereoselective addition of 1-siloxy-isobenzofurans 4a and 4b to iminium ion 5 in a one-pot approach. The synthesis features the use of imine 13 obtained through Bischler–Napieralsky reaction from amine 11. The addition of ionic liquids as addictives in the reactions afforded erythro configuration in major adduct compounds. The synthetic route can also be applied in the total synthesis of promising tubulin binding agent EM105 (3).
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