淋巴系统
血管内皮生长因子C
淋巴管内皮
平足蛋白
生物
淋巴管新生
淋巴管
淋巴结间质细胞
癌症研究
淋巴结
血管内皮生长因子
病理
转移
血管内皮生长因子A
血管内皮生长因子受体
免疫学
癌症
医学
遗传学
作者
Marika J. Karkkainen,Kari Alitalo
标识
DOI:10.1006/scdb.2001.0286
摘要
Vascular endothelial growth factor receptor-3 (VEGFR-3) mediates lymphatic endothelial cell (LEC) growth, migration, and survival by binding VEGF-C and VEGF-D. Recent studies have revealed new regulators of the lymphatic endothelium, such as the transcription factor Prox1, and the cell surface proteins podoplanin and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1). Furthermore, the isolation of LECs now allows detailed molecular studies of the factors regulating the lymphatic vasculature. These studies are aimed at targeting the lymphatic vasculature in the treatment of various diseases, such as tumour metastasis and lymphoedema.
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