平衡
炎症
炎症性肠病
免疫系统
肠上皮
免疫学
疾病
生物
效应器
先天免疫系统
肠粘膜
内科学
细胞生物学
医学
上皮
病理
遗传学
作者
Kevin J. Maloy,Fiona Powrie
出处
期刊:Nature
[Springer Nature]
日期:2011-06-01
卷期号:474 (7351): 298-306
被引量:1551
摘要
Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found in inflammatory bowel disease. It is now evident that immune effector modules that drive intestinal inflammation are conserved across innate and adaptive leukocytes and can be controlled by host regulatory cells. Recent evidence suggests that several factors may tip the balance between homeostasis and intestinal inflammation, presenting future challenges for the development of new therapies for inflammatory bowel disease.
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