Association Between Metabolic Syndrome, Radiographic Knee Osteoarthritis, and Intensity of Knee Pain: Results of a National Survey

The association between MetS and radiographic knee OA can be largely explained by an excessive weight but not by insulin resistance, a key pathophysiology of MetS. Because accumulation of MetS components appears to be associated with a higher intensity of knee pain, independently of weight, appropriate treatment for MetS may be helpful for subjects with knee pain.