TLR9型
生物
断点群集区域
B细胞受体
幼稚B细胞
细胞生物学
B-1电池
Toll样受体9
先天免疫系统
免疫学
获得性免疫系统
记忆B细胞
B细胞
受体
TLR7型
CpG寡核苷酸
CD40
TLR4型
癌症研究
抗原
免疫系统
抗体
抗原提呈细胞
T细胞
基因表达
DNA甲基化
基因
生物化学
作者
Nadia L. Bernasconi,Nobuyuki Onai,Antonio Lanzavecchia
出处
期刊:Blood
[Elsevier BV]
日期:2003-06-01
卷期号:101 (11): 4500-4504
被引量:625
标识
DOI:10.1182/blood-2002-11-3569
摘要
Abstract Toll-like receptors (TLRs) are pattern recognition receptors that trigger innate immunity. In this study we investigated the expression of 10 TLRs in human naive and memory B-cell subsets. We report that in human naive B cells most TLRs are expressed at low to undetectable levels, but the expression of TLR9 and TLR10 is rapidly induced following B-cell-receptor (BCR) triggering. In contrast, memory B cells express several TLRs at constitutively high levels. The differential expression of TLR9 correlates with responsiveness to its agonist, CpG DNA. Thus, human memory B cells proliferate and differentiate to immunoglobulin (Ig)–secreting cells in response to CpG, while naive B do so only if simultaneously triggered through the BCR. The BCR-induced expression of TLRs in human naive B cells prevents polyclonal activation in a primary response, because it restricts stimulation to antigen-specific B cells. In contrast, the constitutive expression of TLRs in memory B cells allows polyclonal activation of the entire memory pool. Thus, in human B cells TLRs are downstream of BCR and play a role both in the primary response and in the memory phase.
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