巴西金
恶性疟原虫
疟疾
病菌
生物
网织红细胞
膜蛋白
微生物学
病毒学
免疫学
生物化学
基因
信使核糖核酸
膜
基质金属蛋白酶
标识
DOI:10.1517/14728222.2012.711818
摘要
Introduction: Malaria is one of the most serious infectious diseases at the beginning of the twenty-first century. Various membrane proteins are present in Plasmodium falciparum, the principal malaria pathogen. Among them, P. falciparum reticulocyte-binding protein homolog 5 (PfRh5) is indispensable for erythrocyte invasion, and has become a promising vaccine target. Basigin (CD147, EMMPRIN) has been identified as the erythrocyte receptor of PfRh5, and shown to be essential for the invasion of multiple strains of the pathogen.
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